alcohol intoxication antidote

2020 Oct;26(4):586-594. doi: 10.3350/cmh.2020.0100. (a) Confocal laser scanning microscopy (CLSM) images of mouse hepatocytes (AML12) after 4 hr incubation with the native AOx–CAT and ALDH, or n(AOx–CAT) and n(ALDH). Both antidotes have advantages and disadvantages. and you may need to create a new Wiley Online Library account. To date, some alcoholics are given Antabuse, a powerful drug that makes alcoholics very sick if they continue to consume alcohol. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use. Such an antidote, which can eliminate alcohol and acetaldehyde simultaneously, holds great promise for the treatment of alcohol intoxication and poisoning and can provide therapeutic benefits. Please enable it to take advantage of the complete set of features! Unlimited viewing of the article/chapter PDF and any associated supplements and figures. [Effect of acetaldehyde on ethanol- and aldehyde-metabolising systems of the liver and brain of rats]. An antidote is the first line of treatment for antifreeze poisoning. Any queries (other than missing content) should be directed to the corresponding author for the article. Epub 2008 May 8. Therapy consists of general supportive care (e.g. Keywords: alcohol detoxification; biomimetic antidotes; enzyme nanocapsules; nanomedicine. Alcohol intoxication causes serious diseases, whereas current treatments are mostly supportive and unable to remove alcohol efficiently. This site needs JavaScript to work properly. Ethanol is readily available in most hospitals, is inexpensive, and can be administered orally as well as intravenously. (a) Alcohol metabolism in hepatocytes. Cytosolic ADH converts alcohol to acetaldehyde with the cofactor NAD. An antidote is a drug, chelating substance, or a chemical that counteracts (neutralizes) the effects of another drug or a poison. Competitively blocks the formation of toxic metabolites in toxic alcohol ingestion by having a higher affinity for the enzyme Alcohol Dehydrogenase (ADH). (d) The kinetics of the removal of alcohol and acetaldehyde in a closed system containing alcohol (0.4%, Delivery and therapeutic efficacy of n(AOx–CAT) and n(ALDH) as the antidote. Inspired by the metabolism of alcohol, a hepatocyte-mimicking antidote for alcohol intoxication through the codelivery of the nanocapsules of alcohol oxidase (AOx), catalase (CAT), and aldehyde dehydrogenase (ALDH) to the liver, where AOx and CAT catalyze the oxidation of alcohol to acetaldehyde, while ALDH catalyzes the oxidation of acetaldehyde to acetate. Han H, He Y, Johnson H, Mishra P, Lee H, Ji C. Alcohol Clin Exp Res. Learn about our remote access options, Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, 90095 USA, Department of Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, 90033 USA, California NanoSystem Institute, Los Angeles, CA, 90095 USA, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071 China. Epub 2020 Sep 17. Please check your email for instructions on resetting your password. Its chief application is in methanol and ethylene glycol ingestion, although it has been used with other toxic alcohols. Alcohol intoxication causes serious diseases, whereas current treatments are mostly supportive and unable to remove alcohol efficiently. 2019 Jun;43(6):1091-1102. doi: 10.1111/acer.14034. Scale bar, 50 μm. Inspired by the metabolism of alcohol, a hepatocyte‐mimicking antidote for alcohol intoxication through the codelivery of the nanocapsules of alcohol oxidase (AOx), catalase (CAT), and aldehyde dehydrogenase (ALDH) to the liver, where AOx and CAT catalyze the oxidation of alcohol to acetaldehyde, while ALDH catalyzes the oxidation of acetaldehyde to acetate. (b) Size and (c) Zeta potentials of n(AOx–CAT) and n(ALDH) measured by dynamic light scattering. Unlimited viewing of the article PDF and any associated supplements and figures. (a) Alcohol metabolism in hepatocytes.…, Characterization of the nanocapsules. (a) Representative H&E and Oil Red O staining of the liver tissues in alcohol–intoxicated mice treated with PBS, or n(AOx–CAT) and n(ALDH) with NAD. (c), (d) Blood alcohol concentrations (BAC) (c) and blood acetaldehyde concentrations (BAchC) (d) of alcohol–intoxicated mice treated with PBS, n(AOx–CAT) and n(ALDH), or n(AOx–CAT) and n(ALDH) with NAD, Biocompatibility of the antidote after HFD and acute alcohol intoxication. Such an antidote, which can eliminate alcohol and acetaldehyde simultaneously, holds great promise for the treatment of alcohol intoxication and poisoning and can provide therapeutic benefits. See this image and copyright information in PMC. Use the link below to share a full-text version of this article with your friends and colleagues. In a pregnant woman with severe metabolically‐toxic alcohol poisoning, an antidote is obligatory, and if fomepizole is not available, ethanol should be used. Get the latest public health information from CDC: https://www.coronavirus.gov. (a)…, Characterization of the nanocapsules. Alcoholism and aldehydism: new biomedical concepts. (a) Representative H&E…, NLM Moreover, blood acetaldehyde concentration is maintained at an extremely low level, significantly contributing to liver protection. Such an antidote, which can eliminate alcohol and acetaldehyde simultaneously, holds great promise for the treatment of alcohol intoxication and poisoning and can provide therapeutic benefits. Administered to alcohol‐intoxicated mice, the antidote rapidly accumulates in the liver and enables a significant reduction of the blood alcohol concentration. Protective Effects of Facilitated Removal of Blood Alcohol and Acetaldehyde Against Liver Injury in Animal Models Fed Alcohol and Anti-HIV Drugs. This study evaluates the potential antidotal effect of naloxone on experimentally induced alcohol intoxication in 12 mongrel dogs.

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